CHST10 Gene Summary [Human]
This protein encoded by this gene transfers sulfate to the C-3 hydroxyl of terminal glucuronic acid of protein- and lipid-linked oligosaccharides. This protein was first identified as a sulfotransferase that acts on the human natural killer-1 (HNK-1) glycan; HNK-1 is a carbohydrate involved in neurodevelopment and synaptic plasticity.[provided by RefSeq, Feb 2011]
Details
| Type | Protein Coding |
| Official Symbol | CHST10 |
| Official Name | carbohydrate sulfotransferase 10 [Source:HGNC Symbol;Acc:HGNC:19650] |
| Ensembl ID | ENSG00000115526 |
| Bio databases IDs | |
| Aliases | carbohydrate sulfotransferase 10 |
| Synonyms | carbohydrate sulfotransferase 10, carbohydrate sulphotransferase 10, HNK-1ST, raHNK-1ST, ST, sul-T |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CHST10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sulfotransferase
- catalytic domain
- enzyme
- Sulfotransferase family
- HNK-1 sulfotransferase
Pathways
Biological processes and signaling networks where the CHST10 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- hyperplasia
role in cell
- expression in
- adhesion
- invasiveness
- migration
- excitatory postsynaptic potential
- long-term potentiation
- glycosylation in
- formation in
- sulfation in
- transmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CHST10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-term memory
- androgen metabolic process
- estrogen metabolic process
- carbohydrate biosynthetic process
- cell adhesion
- proteoglycan biosynthetic process
- learning
Cellular Component
Where in the cell the gene product is active
- membrane
- Golgi membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- HNK-1 sulfotransferase activity
- sulfotransferase activity