HSD17B8 Gene Summary [Human]
In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | HSD17B8 |
| Official Name | hydroxysteroid 17-beta dehydrogenase 8 [Source:HGNC Symbol;Acc:HGNC:3554] |
| Ensembl ID | ENSG00000112474 |
| Bio databases IDs | |
| Aliases | hydroxysteroid 17-beta dehydrogenase 8 |
| Synonyms | D17H6S112E, D6S2245E, dJ1033B10.9, FABG, FABGL, H2-KE6, HKE6, hydroxysteroid (17-beta) dehydrogenase 8, hydroxysteroid 17-beta dehydrogenase 8, hydroxysteroid (17-β) dehydrogenase 8, hydroxysteroid 17-β dehydrogenase 8, KE6, RING2, SDR30C1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HSD17B8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- estradiol 17beta-dehydrogenase
- SDR family mycofactocin-dependent oxidoreductase
- NAD dependent epimerase/dehydratase family
- KR domain
- pteridine reductase
- enzyme
- Enoyl-(Acyl carrier protein) reductase
- protein binding
- polyketide synthase keto reductase domain
- NAD or NADH binding
- 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD)
- binding protein
- 3-oxoacyl-(acyl-carrier-protein) reductase
- acetoacetyl-CoA reductase
- CH-OH group:NAD or NADP oxidoreductase
- acetoin reductases
- short chain dehydrogenase
Pathways
Biological processes and signaling networks where the HSD17B8 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- mitochondrial envelope
- cellular membrane
- Plasma Membrane
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HSD17B8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- estrogen biosynthetic process
- androgen metabolic process
- fatty acid biosynthetic process
- protein heterotetramerization
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrial envelope
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- estradiol 17-beta-dehydrogenase activity
- protein binding
- testosterone dehydrogenase (NAD+) activity
- NADH binding