Hsd17b8 Gene Summary [Rat]
Predicted to enable several functions, including (3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity; NADH binding activity; and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in estrogen biosynthetic process; fatty acid biosynthetic process; and protein heterotetramerization. Predicted to act upstream of or within androgen metabolic process and estrogen metabolic process. Predicted to be located in mitochondrial envelope; mitochondrial matrix; and plasma membrane. Predicted to be part of oxidoreductase complex. Orthologous to human HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hsd17b8 |
| Official Name | hydroxysteroid (17-beta) dehydrogenase 8 [Source:RGD Symbol;Acc:1303158] |
| Ensembl ID | ENSRNOG00000000466 |
| Bio databases IDs | |
| Aliases | hydroxysteroid (17-beta) dehydrogenase 8 |
| Synonyms | D17H6S112E, D6S2245E, dJ1033B10.9, FABG, FABGL, H2-KE6, HKE6, hydroxysteroid (17-beta) dehydrogenase 8, hydroxysteroid 17-beta dehydrogenase 8, hydroxysteroid (17-β) dehydrogenase 8, hydroxysteroid 17-β dehydrogenase 8, KE6, RING2, SDR30C1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hsd17b8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- estradiol 17beta-dehydrogenase
- SDR family mycofactocin-dependent oxidoreductase
- NAD dependent epimerase/dehydratase family
- KR domain
- pteridine reductase
- enzyme
- Enoyl-(Acyl carrier protein) reductase
- protein binding
- polyketide synthase keto reductase domain
- NAD or NADH binding
- 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD)
- binding protein
- 3-oxoacyl-(acyl-carrier-protein) reductase
- acetoacetyl-CoA reductase
- CH-OH group:NAD or NADP oxidoreductase
- acetoin reductases
- short chain dehydrogenase
Pathways
Biological processes and signaling networks where the Hsd17b8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- mitochondrial envelope
- cellular membrane
- Plasma Membrane
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hsd17b8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- estrogen biosynthetic process
- androgen metabolic process
- fatty acid biosynthetic process
- protein heterotetramerization
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrial envelope
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- estradiol 17-beta-dehydrogenase activity
- protein binding
- testosterone dehydrogenase (NAD+) activity
- NADH binding