H2-Ke6 Gene Summary [Mouse]
Enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity and testosterone dehydrogenase (NAD+) activity. Acts upstream of or within androgen metabolic process and estrogen metabolic process. Located in mitochondrial envelope and plasma membrane. Is expressed in several structures, including brain; genitourinary system; heart; hemolymphoid system gland; and liver. Orthologous to human HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | H2-Ke6 |
| Official Name | H2-K region expressed gene 6 [Source:MGI Symbol;Acc:MGI:95911] |
| Ensembl ID | ENSMUSG00000073422 |
| Bio databases IDs | |
| Aliases | H2-K region expressed gene 6 |
| Synonyms | D17H6S112E, D6S2245E, dJ1033B10.9, FABG, FABGL, H2-KE6, HKE6, hydroxysteroid (17-beta) dehydrogenase 8, hydroxysteroid 17-beta dehydrogenase 8, hydroxysteroid (17-β) dehydrogenase 8, hydroxysteroid 17-β dehydrogenase 8, KE6, RING2, SDR30C1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse H2-Ke6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- estradiol 17beta-dehydrogenase
- SDR family mycofactocin-dependent oxidoreductase
- NAD dependent epimerase/dehydratase family
- KR domain
- pteridine reductase
- enzyme
- Enoyl-(Acyl carrier protein) reductase
- protein binding
- polyketide synthase keto reductase domain
- NAD or NADH binding
- 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD)
- binding protein
- 3-oxoacyl-(acyl-carrier-protein) reductase
- acetoacetyl-CoA reductase
- CH-OH group:NAD or NADP oxidoreductase
- acetoin reductases
- short chain dehydrogenase
Pathways
Biological processes and signaling networks where the H2-Ke6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- mitochondrial envelope
- cellular membrane
- Plasma Membrane
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse H2-Ke6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- estrogen biosynthetic process
- androgen metabolic process
- fatty acid biosynthetic process
- protein heterotetramerization
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrial envelope
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- estradiol 17-beta-dehydrogenase activity
- protein binding
- testosterone dehydrogenase (NAD+) activity
- NADH binding