PRPF4B Gene Summary [Human]
Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | PRPF4B |
| Official Name | pre-mRNA processing factor 4B [Source:HGNC Symbol;Acc:HGNC:17346] |
| Ensembl ID | ENSG00000112739 |
| Bio databases IDs | |
| Aliases | pre-mRNA processing factor 4B |
| Synonyms | 2610037H07, cbp143, dJ1013A10.1, PR4H, pre-mRNA processing factor 4B, pre-mRNA processing factor kinase PRP4K, PRP4, Prp4B, PRP4H, PRPF4B, Prpk |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRPF4B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- arginine serine dipeptide repeat domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- alcohol group acceptor phosphotransferase
- SR domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the PRPF4B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- catalytic step 2 spliceosome
- spliceosomes
- chromosome
- nucleoplasm
- nuclear speckles
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRPF4B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nuclear mRNA cis splicing, via spliceosome
- positive regulation of hippo signaling cascade
- positive regulation of protein export from nucleus
- regulation of mitotic cell cycle spindle assembly checkpoint
- protein phosphorylation
- spliceosomal snRNP assembly
- assembly of spliceosomal tri-snRNP
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- catalytic step 2 spliceosome
- nuclear speck
- kinetochore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- RNA binding
- protein serine/threonine kinase activity