TENT4A Gene Summary [Human]
The protein encoded by this gene is a DNA polymerase that is likely involved in DNA repair. In addition, the encoded protein may be required for sister chromatid adhesion. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jan 2010]
Details
| Type | Protein Coding |
| Official Symbol | TENT4A |
| Official Name | terminal nucleotidyltransferase 4A [Source:HGNC Symbol;Acc:HGNC:16705] |
| Ensembl ID | ENSG00000112941 |
| Bio databases IDs | |
| Aliases | terminal nucleotidyltransferase 4A, topoisomerase-related function protein 4-1, polymerase (DNA-directed) sigma, DNA polymerase kappa, TUTase5 |
| Synonyms | DNA polymerase sigma, DNA polymerase σ, LAK-1, PAPD7, POLK, POLS, POLYMERASE SIGMA, POLYMERASE σ, terminal nucleotidyltransferase 4A, TRF4, TRF4-1, TUTASE5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TENT4A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cid1 family poly A polymerase
- Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
- nucleotidyltransferase
- enzyme
- protein binding
- Polymerase beta, Nucleotidyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Golgi Apparatus
- nucleoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TENT4A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA 3' uridylation
- sister chromatid cohesion
- negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
- mitotic chromosome condensation
- RNA 3'-end processing
- response to xenobiotic stimulus
- mRNA processing
- double-strand break repair
- polyadenylation-dependent ncRNA catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- Golgi apparatus
- nucleolus
- TRAMP complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- metal ion binding
- SMC protein binding
- guanylyltransferase activity