GNPDA1 Gene Summary [Human]
Glucosamine-6-phosphate deaminase (EC 3.5.99.6) is an allosteric enzyme that catalyzes the reversible conversion of D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium (Arreola et al., 2003 [PubMed 12965206]).[supplied by OMIM, Jan 2010]
Details
| Type | Protein Coding |
| Official Symbol | GNPDA1 |
| Official Name | glucosamine-6-phosphate deaminase 1 [Source:HGNC Symbol;Acc:HGNC:4417] |
| Ensembl ID | ENSG00000113552 |
| Bio databases IDs | |
| Aliases | glucosamine-6-phosphate deaminase 1, glucosamine-6-phosphate deaminase, oscillin |
| Synonyms | GlcN6P deaminase, glucosamine-6-phosphate deaminase 1, GNP1, GNPDA, GNPI, GPI, HLN, oscillin |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GNPDA1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SugarP_isomerase
- Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
- glucosamine-6-phosphate deaminase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- cytoplasmic droplets
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GNPDA1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- generation of precursor metabolites and energy
- glucosamine catabolic process
- N-acetylneuraminate catabolic process
- N-acetylglucosamine catabolic process
- single fertilization
- UDP-N-acetylglucosamine biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- glucosamine-6-phosphate deaminase activity
- isomerase activity