FGL2 Gene Summary [Human]
The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FGL2 |
| Official Name | fibrinogen like 2 [Source:HGNC Symbol;Acc:HGNC:3696] |
| Ensembl ID | ENSG00000127951 |
| Bio databases IDs | |
| Aliases | fibrinogen like 2, fibroleukin |
| Synonyms | fibrinogen-like 2, fibrinogen-like protein 2, FIBROLEUKIN, musfiblp, PCA protein (70 kDa), pT49, T49 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FGL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- protein binding
- protease activator
- FReD
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Waldenström macroglobulinemia
- COVID-19
- diabetes mellitus
- uterine serous papillary cancer
- endometriosis
- systemic juvenile idiopathic arthritis
- colorectal cancer
- diabetic peripheral neuropathy
- hypertrophic scarring
- lupus-like autoimmune disease
role in cell
- apoptosis
- production in
- proliferation
- necrosis
- differentiation
- frequency
- cellular infiltration by
- infiltration by
- class switching in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- ficolin-1-rich granule lumen
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FGL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of memory T cell differentiation
- T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
- negative regulation of dendritic cell antigen processing and presentation
- negative regulation of macrophage antigen processing and presentation
- negative regulation of defense response to virus
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular region
- fibrinogen complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- extracellular matrix structural constituent