Smc4 Gene Summary [Mouse]
Enables chromatin binding activity and single-stranded DNA binding activity. Involved in positive regulation of chromosome segregation and positive regulation of chromosome separation. Acts upstream of or within kinetochore organization; meiotic chromosome condensation; and meiotic chromosome segregation. Located in chromosome, centromeric region and condensed nuclear chromosome. Part of condensin complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human SMC4 (structural maintenance of chromosomes 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smc4 |
| Official Name | structural maintenance of chromosomes 4 [Source:MGI Symbol;Acc:MGI:1917349] |
| Ensembl ID | ENSMUSG00000034349 |
| Bio databases IDs | |
| Aliases | structural maintenance of chromosomes 4 |
| Synonyms | 2500002A22Rik, CAP-C, DKFZP434F205, SMC4L1, structural maintenance of chromosomes 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Smc4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chromosome segregation protein SMC, primarily archaeal type
- SMC proteins Flexible Hinge Domain
- exonuclease SbcC
- ATP binding
- helix-rich Mycoplasma protein
- chromatin binding
- protein binding
- Laminin Domain I
- AAA domain
- chromosome segregation protein SMC, common bacterial type
- RecF/RecN/SMC N terminal domain
- single-stranded DNA binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- non-insulin-dependent diabetes mellitus
- Alzheimer disease
- serous ovarian adenocarcinoma
- serous ovarian cancer
- Hutchinson-Gilford progeria syndrome
- prostate cancer
- major depression
- androgenic alopecia
- primary ovarian cancer
role in cell
- proliferation
- survival
- cell viability
- organization
- condensation
- segregation
- alignment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- chromosome
- nucleoplasm
- nucleoli
- nuclear scaffolds
- nuclear speckles
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Smc4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- positive regulation of chromosome segregation
- meiotic chromosome condensation
- mitotic chromosome condensation
- kinetochore organization
- meiotic chromosome segregation
- mitotic sister chromatid segregation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- cytosol
- chromosome, centromeric region
- condensin complex
- condensed nuclear chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- chromatin binding
- single-stranded DNA binding