NCBP2 Gene Summary [Human]
The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | NCBP2 |
| Official Name | nuclear cap binding protein subunit 2 [Source:HGNC Symbol;Acc:HGNC:7659] |
| Ensembl ID | ENSG00000114503 |
| Bio databases IDs | |
| Aliases | nuclear cap binding protein subunit 2 |
| Synonyms | 5930413E18Rik, AI843301, CBC2, CBP20, LOC100911481, LOC108348149, NCBP 20 kDa subunit, NIP1, nuclear cap binding protein subunit 2, PIG55, Pigz |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NCBP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- snRNA binding
- RNA recognition motif (RRM) superfamily
- RNA 7-methylguanosine cap binding
- RNA recognition motif
- mRNA binding
- protein binding
- Occluded RNA-recognition motif
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- organismal death
role in cell
- phosphorylation in
- expression in
- sphere formation
- proliferation
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- basal bodies
- cytosol
- spliceosomes
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NCBP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA transcription from RNA polymerase II promoter
- RNA splicing
- posttranscriptional gene silencing by RNA
- primary miRNA processing
- gene silencing by miRNA
- cap-dependent translational initiation
- histone mRNA metabolic process
- regulation of translational initiation
- positive regulation of RNA export from nucleus
- nuclear mRNA splicing, via spliceosome
- mRNA export from nucleus
- positive regulation of transcription elongation from RNA polymerase II promoter
- nuclear mRNA cis splicing, via spliceosome
- mRNA metabolic process
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- snRNA export from nucleus
- alternative nuclear mRNA splicing, via spliceosome
- positive regulation of mRNA 3'-end processing
- mRNA 3'-end processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear cap binding complex
- RNA cap binding complex
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA 7-methylguanosine cap binding
- protein binding
- RNA binding
- RNA cap binding
- mRNA binding
- snRNA binding