VIPR1 Gene Summary [Human]
This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | VIPR1 |
| Official Name | vasoactive intestinal peptide receptor 1 [Source:HGNC Symbol;Acc:HGNC:12694] |
| Ensembl ID | ENSG00000114812 |
| Bio databases IDs | |
| Aliases | vasoactive intestinal peptide receptor 1, VIP and PACAP receptor 1 |
| Synonyms | AV071699, HVR1, II, INTESTINAL VIP receptor RELATED, PACAP-R-2, PACAP receptor type ii, Pvr2, RATVASREC, RDC1, RGD1564352, V1RG, VAPC1, vasoactive intestinal peptide receptor 1, VASREC, Vip1 Receptor, VIPR, VIRG, VPAC1, VPAC1R, Vpac1 receptor, VPCAP1R |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human VIPR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Hormone receptor domain
- 7 transmembrane receptor (Secretin family)
- extracellular domain
- transmembrane domain
- intracellular domain
- protein binding
- cytosolic tail domain
- seven-transmembrane G protein-coupled receptor superfamily
- pituitary adenylate cyclase activating protein receptor
- polypeptide hormone binding
- vasoactive intestinal polypeptide receptor
Pathways
Biological processes and signaling networks where the VIPR1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- cancer
- rheumatoid arthritis
- small cell lung cancer
- growth failure
- colon cancer
- idiopathic pulmonary fibrosis
- hypoglycemia
- Huntington disease
role in cell
- proliferation
- binding
- production in
- activation
- chemotaxis
- activation-induced cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human VIPR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- positive regulation of cell proliferation
- cell surface receptor signaling pathway
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled peptide receptor activity
- vasoactive intestinal polypeptide receptor activity
- protein binding
- peptide hormone binding