DCAF13 Gene Summary [Human]
Enables estrogen receptor binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in several cellular components, including centrosome; cytosol; and nuclear lumen. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DCAF13 |
| Official Name | DDB1 and CUL4 associated factor 13 [Source:HGNC Symbol;Acc:HGNC:24535] |
| Ensembl ID | ENSG00000164934 |
| Bio databases IDs | |
| Aliases | DDB1 and CUL4 associated factor 13 |
| Synonyms | DDB1 and CUL4 associated factor 13, GM83, HSPC064, Sof1, WDSOF1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DCAF13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- protein binding activity, bridging
- WD domain, G-beta repeat
- WD40
- protein binding
- estrogen receptor binding
- Sof1-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- lung adenocarcinoma
- lung adenocarcinoma formation
- infection by vesicular stomatitis virus
role in cell
- growth
- proliferation
- migration
- expression in
- apoptosis
- transformation
- polyubiquitination in
- K48 polyubiquitination in
- degradation in
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cell junction
- centrosome
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DCAF13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- proteasomal ubiquitin-dependent protein catabolic process
- oocyte growth
- spindle assembly involved in female meiosis
- decidualization
- rRNA processing
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- centrosome
- cell junction
- cytosol
- nucleolus
- CUL4 RING ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- estrogen receptor binding