LMAN2L Gene Summary [Human]
This gene encodes a protein belonging to the L-type lectin group of type 1 membrane proteins, which function in the mammalian early secretory pathway. These proteins contain luminal carbohydrate recognition domains, which display homology to leguminous lectins. Unlike other proteins of the group, which cycle in the early secretory pathway and are predominantly associated with post endoplasmic reticulum membranes, the protein encoded by this gene is a non-cycling resident protein of the ER, where it functions as a cargo receptor for glycoproteins. It is proposed to regulate exchange of folded proteins for transport to the Golgi and exchange of misfolded glycoproteins for transport to the ubiquitin-proteasome pathway. [provided by RefSeq, Apr 2016]
Details
| Type | Protein Coding |
| Official Symbol | LMAN2L |
| Official Name | lectin, mannose binding 2 like [Source:HGNC Symbol;Acc:HGNC:19263] |
| Ensembl ID | ENSG00000114988 |
| Bio databases IDs | |
| Aliases | lectin, mannose binding 2 like, VIP36-like |
| Synonyms | A630028F14Rik, lectin, mannose-binding 2-like, LOC120094667, MRD69, MRT52, VIP36-like, VIPL |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LMAN2L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Bacterial lectin
- legume lectins
- protein binding
- mannose binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- bipolar disorder
- autosomal recessive mental retardation
- renal clear cell adenocarcinoma
- renal clear cell cancer
- autosomal recessive mental retardation type 52
- autosomal dominant intellectual developmental disorder type 69
regulates
- glycoprotein
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LMAN2L gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- protein transport
- protein folding
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- Golgi membrane
- Golgi apparatus
- ER to Golgi transport vesicle
- endoplasmic reticulum-Golgi intermediate compartment
Molecular Function
What the gene product does at the molecular level
- mannose binding
- protein binding
- metal ion binding