GCA Gene Summary [Human]
This gene encodes a calcium-binding protein that is abundant in neutrophils and macrophages. In the absence of divalent cation, this protein localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions. Alternative splicing and use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Details
| Type | Processed Transcript |
| Official Symbol | GCA |
| Official Name | grancalcin [Source:HGNC Symbol;Acc:HGNC:15990] |
| Ensembl ID | ENSG00000115271 |
| Bio databases IDs | |
| Aliases | grancalcin |
| Synonyms | 5133401E04Rik, GCL, grancalcin, LOC101929553 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GCA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- The penta-EF hand (PEF) family
- EF-hand domain pair
- calcium ion binding
- protein homodimerization
- EFh
- protein binding
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
- rheumatoid arthritis
- non-insulin-dependent diabetes mellitus
- psoriasis
- endotoxin shock response
- impaired glucose tolerance
role in cell
- expression in
- cellular infiltration by
- phosphorylation in
- activation in
- production in
- quantity
- fusion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- azurophil granule lumen
- Extracellular Space
- cellular membrane
- Plasma Membrane
- granules
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GCA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane fusion
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
- extracellular region
- plasma membrane
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- protein heterodimerization activity
- calcium ion binding