ICMT Gene Summary [Human]
This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ICMT |
| Official Name | isoprenylcysteine carboxyl methyltransferase [Source:HGNC Symbol;Acc:HGNC:5350] |
| Ensembl ID | ENSG00000116237 |
| Bio databases IDs | |
| Aliases | isoprenylcysteine carboxyl methyltransferase, protein-S-isoprenylcysteine O-methyltransferase |
| Synonyms | 1700008E11RIK, fcmt, Gm13095, HSTE14, isoprenylcysteine carboxyl methyltransferase, MST098, MSTP098, PCCMT, PCMT, PPMT, STE14 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ICMT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein-S-isoprenylcysteine O-methyltransferase
- cAMP response element binding protein binding
- C-terminal protein carboxyl methyltransferase
- enzyme
- protein binding
- Isoprenylcysteine carboxyl methyltransferase (ICMT) family
Pathways
Biological processes and signaling networks where the ICMT gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cervical cancer
- metastasis
- epithelial uterine cancer
- tumorigenesis
- abdominal aortic aneurysm
- developmental delay
- cervical small cell carcinoma
- extrapulmonary small cell cancer
role in cell
- growth
- cell viability
- apoptosis
- cell death
- response
- proliferation
- migration
- colony formation
- self-renewal
- association
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- ribosome
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ICMT gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- S-adenosylhomocysteine metabolic process
- C-terminal protein methylation
- S-adenosylmethioninamine metabolic process
- protein targeting to membrane
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
- protein C-terminal carboxyl O-methyltransferase activity