Gca Gene Summary [Mouse]
Predicted to enable calcium ion binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be located in cytosol and plasma membrane. Is expressed in cerebral cortex ventricular layer and telencephalon ventricular layer. Orthologous to human GCA (grancalcin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gca |
| Official Name | grancalcin [Source:MGI Symbol;Acc:MGI:1918521] |
| Ensembl ID | ENSMUSG00000026893 |
| Bio databases IDs | |
| Aliases | grancalcin |
| Synonyms | 5133401E04Rik, GCL, grancalcin, LOC101929553 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gca often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- The penta-EF hand (PEF) family
- EF-hand domain pair
- calcium ion binding
- protein homodimerization
- EFh
- protein binding
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
- rheumatoid arthritis
- non-insulin-dependent diabetes mellitus
- psoriasis
- endotoxin shock response
- impaired glucose tolerance
role in cell
- expression in
- cellular infiltration by
- phosphorylation in
- activation in
- production in
- quantity
- fusion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- azurophil granule lumen
- Extracellular Space
- cellular membrane
- Plasma Membrane
- granules
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gca gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane fusion
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
- extracellular region
- plasma membrane
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- protein heterodimerization activity
- calcium ion binding