Wdr75 Gene Summary [Mouse]

Predicted to enable RNA binding activity. Predicted to be involved in positive regulation of rRNA processing; positive regulation of transcription by RNA polymerase I; and ribosomal small subunit biogenesis. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in pancreas epithelium. Orthologous to human WDR75 (WD repeat domain 75). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
Wdr75
Official Name
WD repeat domain 75 [Source:MGI Symbol;Acc:MGI:1920924]
Ensembl ID
ENSMUSG00000025995
Bio databases IDs NCBI: 73674 Ensembl: ENSMUSG00000025995
Aliases WD repeat domain 75
Synonyms 1300003A18Rik, 2410118I19RIK, C77608, LRRG00118, NET16, UTP17, WD repeat domain 75
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wdr75 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • WD40 repeats
  • WD domain, G-beta repeat
  • WD40
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
regulates
  • 47S PRE-RRNA
  • rDNA
role in cell
  • processing in
  • transcription in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • pre-ribosome
  • nucleoplasm
  • nucleoli

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Wdr75 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • ribosomal small subunit biogenesis
  • positive regulation of rRNA processing
  • rRNA processing
  • positive regulation of transcription from RNA polymerase I promoter

Cellular Component

Where in the cell the gene product is active
  • small-subunit processome
  • nucleolus
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • RNA binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.