PDCL3 Gene Summary [Human]
This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PDCL3 |
| Official Name | phosducin like 3 [Source:HGNC Symbol;Acc:HGNC:28860] |
| Ensembl ID | ENSG00000115539 |
| Bio databases IDs | |
| Aliases | phosducin like 3 |
| Synonyms | 1110061A19Rik, HTPHLP, PHLP2A, PHLP3, phosducin-like 3, VIAF, VIAF1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PDCL3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- tail domain
- protein binding
- vascular endothelial growth factor receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- cytosol
- perinucleolar compartments
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PDCL3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of peptidyl-tyrosine phosphorylation
- angiogenesis
- positive regulation of gene expression
- apoptotic process
- chaperone-mediated protein folding
- positive regulation of endothelial cell proliferation
- protein folding
- protein stabilization
- actin cytoskeleton organization
- positive regulation of angiogenesis
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- endoplasmic reticulum
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein binding involved in protein folding
- vascular endothelial growth factor receptor 2 binding