PDCD5 Gene Summary [Human]
This gene encodes a protein that is upregulated during apoptosis where it translocates rapidly from the cytoplasm to the nucleus. The encoded protein may be an important regulator of K(lysine) acetyltransferase 5 (a protein involved in transcription, DNA damage response and cell cycle control) by inhibiting its proteasome-dependent degradation. Pseudogenes have been identified on chromosomes 5 and 12 [provided by RefSeq, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | PDCD5 |
| Official Name | programmed cell death 5 [Source:HGNC Symbol;Acc:HGNC:8764] |
| Ensembl ID | ENSG00000105185 |
| Bio databases IDs | |
| Aliases | programmed cell death 5, TFAR19 novel apoptosis-related, TF1 cell apoptosis-related gene 19 |
| Synonyms | 2200003D22Rik, NEWGENE 1310561, programmed cell death 5, TFAR19 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PDCD5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- protein binding
- enzyme activator activity
- heparin binding
- Double-stranded DNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic pulmonary fibrosis
- systemic lupus erythematosus
- Alzheimer disease
- dilated cardiomyopathy
- metastasis
- cardiac hypertrophy
- heart failure
- renal cell carcinoma
- renal cell cancer
- fibrosis
role in cell
- apoptosis
- activation in
- binding in
- ubiquitination in
- interaction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cell periphery
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PDCD5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- cellular response to transforming growth factor beta stimulus
- negative regulation of cell proliferation
- positive regulation of gene expression
- positive regulation of apoptotic process
- apoptotic process
- positive regulation of release of cytochrome c from mitochondria
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- beta-tubulin binding
- acetyltransferase activator activity
- heparin binding