MPO Gene Summary [Human]
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
Details
| Type | Protein Coding |
| Official Symbol | MPO |
| Official Name | myeloperoxidase [Source:HGNC Symbol;Acc:HGNC:7218] |
| Ensembl ID | ENSG00000005381 |
| Bio databases IDs | |
| Aliases | myeloperoxidase |
| Synonyms | mKIAA4033, myeloperoxidase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MPO often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peroxidase
- peroxidase (miscellaneous)
- Animal haem peroxidase
- chromatin binding
- enzyme
- protein binding
- Animal heme peroxidases and related proteins
- heparin binding
Pathways
Biological processes and signaling networks where the MPO gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute coronary syndrome
- sepsis
- tuberculosis
- systemic lupus erythematosus
- fibrosis
- hepatic fibrosis
- acute myeloid leukemia
- mixed phenotype acute leukemia
- colitis
- bleeding
role in cell
- stimulation
- expression in
- recruitment
- activation
- production in
- cell death
- cellular infiltration by
- migration
- degranulation
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- azurophil granule lumen
- cell surface
- Extracellular Space
- cell periphery
- perinuclear region
- organelle lumens
- Nucleus
- vacuole
- Plasma Membrane
- vesicles
- lysosome
- granules
- nucleoplasm
- gelatinase granules
- azurophil granules
- specific granules
- secretory granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MPO gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to food
- low-density lipoprotein particle remodeling
- defense response
- defense response to bacterium
- hydrogen peroxide catabolic process
- response to mechanical stimulus
- response to oxidative stress
- hypochlorous acid biosynthetic process
- respiratory burst involved in defense response
- negative regulation of apoptotic process
- removal of superoxide radicals
- response to yeast
- response to lipopolysaccharide
- defense response to fungus
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- phagocytic vesicle lumen
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- secretory granule
- azurophil granule
- extracellular region
- azurophil granule lumen
- nucleoplasm
- lysosome
Molecular Function
What the gene product does at the molecular level
- peroxidase activity
- protein binding
- metal ion binding
- heparin binding
- chromatin binding
- heme binding