Cebpz Gene Summary [Mouse]
Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of CCAAT-binding activity factor complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; bone; brain; genitourinary system; and hemolymphoid system gland. Orthologous to human CEBPZ (CCAAT enhancer binding protein zeta). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cebpz |
| Official Name | CCAAT/enhancer binding protein zeta [Source:MGI Symbol;Acc:MGI:109386] |
| Ensembl ID | ENSMUSG00000024081 |
| Bio databases IDs | |
| Aliases | CCAAT/enhancer binding protein zeta |
| Synonyms | CBF, CBF2, Cbf/hsp70, CCAAT-binding factor, CCAAT enhancer binding protein zeta, CCAAT/enhancer binding protein zeta, CCAAT enhancer binding protein ζ, CCAAT/enhancer binding protein ζ, CEBPA-RS1, C/EBP ZETA, C/EBP ζ, HSP-CBF, NOC1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cebpz often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- protein binding
- glutamine-rich domain
- CBF/Mak21 family
Pathways
Biological processes and signaling networks where the Cebpz gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- de novo acute myeloid leukemia
role in cell
- expression in
- structural integrity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cebpz gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- CCAAT-binding factor complex
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA binding
- transcription coactivator activity