GBP3 Gene Summary [Human]
This gene encodes a member of the guanylate-binding protein (GBP) family. GBPs specifically bind guanine nucleotides (GMP, GDP, and GTP) and contain two of the three consensus motifs found in typical GTP-binding proteins. The encoded protein interacts with a member of the germinal center kinase family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2017]
Details
| Type | Retained Intron |
| Official Symbol | GBP3 |
| Official Name | guanylate binding protein 3 [Source:HGNC Symbol;Acc:HGNC:4184] |
| Ensembl ID | ENSG00000117226 |
| Bio databases IDs | |
| Aliases | guanylate binding protein 3 |
| Synonyms | guanylate binding protein 3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GBP3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Guanylate-binding protein, N-terminal domain
- protein homodimerization
- enzyme
- protein binding
- identical protein binding
- Guanylate-binding protein, C-terminal domain
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- placenta accreta spectrum
role in cell
- expression in
- apoptosis
- damage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GBP3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to lipopolysaccharide
- cellular response to interleukin-1
- defense response to virus
- cellular response to tumor necrosis factor
- cellular response to interferon-gamma
- cytolysis in other organism
- defense response to bacterium
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- cytoplasmic vesicle
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- identical protein binding
- protein homodimerization activity
- protein binding
- GTPase activity