CDK18 Gene Summary [Human]
Predicted to enable ATP binding activity; cyclin-dependent protein serine/threonine kinase activity; and protein serine kinase activity. Predicted to be involved in protein phosphorylation and regulation of transcription involved in G1/S transition of mitotic cell cycle. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | CDK18 |
| Official Name | cyclin dependent kinase 18 [Source:HGNC Symbol;Acc:HGNC:8751] |
| Ensembl ID | ENSG00000117266 |
| Bio databases IDs | |
| Aliases | cyclin dependent kinase 18 |
| Synonyms | Ctk18, cyclin-dependent kinase 18, PCTAIRE, PCTAIRE3, PCTK3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDK18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- alcohol group acceptor phosphotransferase
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the CDK18 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- epithelial neoplasia
- epithelial cancer
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- cholangiocarcinoma cancer
- bile duct cancer
- biliary tract cancer
regulates
- F Actin
- CCNA2
- cofilin
role in cell
- phosphorylation in
- accumulation in
- ciliogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDK18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell cycle
- protein phosphorylation
- positive regulation of myelination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- cyclin-dependent protein kinase activity