MTUS2 Gene Summary [Human]
Enables microtubule binding activity and protein homodimerization activity. Part of nucleus. Colocalizes with centrosome and cytoplasmic microtubule. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MTUS2 |
| Official Name | microtubule associated scaffold protein 2 [Source:HGNC Symbol;Acc:HGNC:20595] |
| Ensembl ID | ENSG00000132938 |
| Bio databases IDs | |
| Aliases | microtubule associated scaffold protein 2, +TIP of 150 kDa, cardiac zipper protein |
| Synonyms | 5730592G18Rik, A730013O20Rik, C130038G02Rik, CAZIP, Gm763, ICIS, KIAA0774, microtubule associated scaffold protein 2, microtubule associated tumor suppressor candidate 2, microtubule associated tumour suppressor candidate 2, mKIAA0774, RGD1562533, TIP150 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MTUS2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPEC
- Coiled-coil region of CCDC155 or KASH
- Septum formation initiator
- Tropomyosin like
- Ezrin/radixin/moesin, alpha-helical domain
- Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins
- protein binding
- Bin/Amphiphysin/Rvs domain
- microtubule binding
- Tropomyosin
- Family with sequence similarity 184, A and B
- Growth-arrest specific micro-tubule binding
- protein homodimerization
- Intermediate filament protein
- Cell division protein ZapB
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- fibromuscular dysplasia
- schizophrenia
- hypertension
- breast cancer
- idiopathic scoliosis
- ovarian carcinoma
- epithelial ovarian cancer
- luminal A breast carcinoma
- luminal A breast cancer
role in cell
- attachment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule cytoskeleton
- centrosome
- cytoplasmic bridges
- cytoplasmic microtubule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MTUS2 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- nucleus
- intercellular bridge
- microtubule cytoskeleton
- centrosome
- cytoplasm
- cytoplasmic microtubule
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- microtubule binding