SLC8A2 Gene Summary [Human]
Predicted to enable calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration and calcium:sodium antiporter activity. Predicted to be involved in several processes, including inorganic cation transmembrane transport; learning or memory; and regulation of short-term neuronal synaptic plasticity. Predicted to act upstream of or within several processes, including modulation of chemical synaptic transmission; regulation of action potential firing pattern; and response to ischemia. Part of presynapse. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SLC8A2 |
| Official Name | solute carrier family 8 member A2 [Source:HGNC Symbol;Acc:HGNC:11069] |
| Ensembl ID | ENSG00000118160 |
| Bio databases IDs | |
| Aliases | solute carrier family 8 member A2 |
| Synonyms | NCX2, SLC8A, solute carrier family 8 member A2, solute carrier family 8 (sodium/calcium exchanger), member 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC8A2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium:sodium antiporter
- calcium ion transporter
- sodium ion transporter
- cytoplasmic loop
- calcium:cation antiporter
- sodium/calcium exchanger 1
- C-terminal extension of sodium/calcium exchanger domain
- Sodium/calcium exchanger protein
- protein binding
- Calx-beta domain
- Domains in Na-Ca exchangers and integrin-beta4
- transporter
Pathways
Biological processes and signaling networks where the SLC8A2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microsomal fraction
- presynaptic regions
- cellular membrane
- microtubules
- postsynaptic membrane
- dendritic spines
- synaptic vesicles
- synapse
- cellular protrusions
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC8A2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synapse organization
- cell communication
- cytosolic calcium ion homeostasis
- learning
- memory
- cellular calcium ion homeostasis
- learning or memory
- neuron homeostasis
- ion transport
- response to ischemia
- cognition
- regulation of gene expression
- calcium ion transmembrane transport
- long-term synaptic potentiation
- sodium ion transmembrane transport
- regulation of short-term neuronal synaptic plasticity
- positive regulation of protein serine/threonine kinase activity
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- dendrite
- sarcolemma
- dendritic spine
- synapse
- neuronal cell body
- perikaryon
- basolateral plasma membrane
- axon
- axon terminus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- metal ion binding
- calcium ion transmembrane transporter activity
- sodium ion transmembrane transporter activity
- calcium:sodium antiporter activity