KLF7 Gene Summary [Human]
The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Details
| Type | Protein Coding |
| Official Symbol | KLF7 |
| Official Name | Kruppel like factor 7 [Source:HGNC Symbol;Acc:HGNC:6350] |
| Ensembl ID | ENSG00000118263 |
| Bio databases IDs | |
| Aliases | Kruppel like factor 7, KLF transcription factor 7, ubiquitous Kruppel-like factor |
| Synonyms | 9830124P08Rik, KLF transcription factor 7, Kruppel-like transcription factor 7 (ubiquitous), LOC120094803, Ufa, UKLF |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KLF7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- DNA binding domain
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- zinc ion binding
- double-stranded DNA binding
- Zinc-finger double domain
- N-terminal domain of Kruppel-like factor (KLF) 6, KLF7, and similar proteins
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- organismal death
- neoplasia
- metastasis
- colon adenocarcinoma
- colon epithelial cancer
- prostate cancer
- epithelial cancer
- prostatic carcinoma
- metabolic syndrome X
role in cell
- proliferation
- phosphorylation in
- expression in
- loss
- growth
- apoptosis
- transactivation in
- differentiation
- quantity
- glycolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- chromatin
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KLF7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of insulin secretion involved in cellular response to glucose stimulus
- axonogenesis
- glucose homeostasis
- axon guidance
- positive regulation of transcription from RNA polymerase II promoter
- regulation of epidermal cell differentiation
- dendrite morphogenesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity