EPN1 Gene Summary [Human]
This gene encodes a member of the epsin protein family. The encoded protein binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Loss of function of this gene is associated with reduced tumor growth and progression in certain cancer types. [provided by RefSeq, Mar 2016]
Details
| Type | Protein Coding |
| Official Symbol | EPN1 |
| Official Name | epsin 1 [Source:HGNC Symbol;Acc:HGNC:21604] |
| Ensembl ID | ENSG00000063245 |
| Bio databases IDs | |
| Aliases | epsin 1 |
| Synonyms | EPSIN, Epsin 1, Ibp1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EPN1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin binding domain
- alpha helix
- DPW domain
- protein binding activity, bridging
- NPF motif
- ion channel binding
- VHS, ENTH and ANTH domain superfamily
- protein binding
- ENTH domain
Pathways
Biological processes and signaling networks where the EPN1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- weight gain
- insomnia
- breast adenocarcinoma
- infection by Dengue virus 2
role in cell
- internalization in
- morphology
- remodeling
- remodeling in
- assembly
- outgrowth
- Clathrin mediated endocytosis by
- fission
- endocytosis
- receptor-mediated endocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- presynaptic regions
- postsynaptic region
- Nucleus
- Golgi Apparatus
- endocytic nucleation point
- cytosol
- presynaptic membrane
- postsynaptic membrane
- trans Golgi network
- synaptic vesicles
- nerve ending
- synapse
- clathrin-coated pits
- clathrin-coated vesicles
- synaptosomal fractions
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EPN1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Notch signaling pathway
- in utero embryonic development
- female pregnancy
- embryonic organ development
- endocytosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- endosome
- coated pit
- cytosol
- clathrin vesicle coat
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- clathrin binding
- phospholipid binding