BRMS1 Gene Summary [Human]
This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | BRMS1 |
| Official Name | BRMS1 transcriptional repressor and anoikis regulator [Source:HGNC Symbol;Acc:HGNC:17262] |
| Ensembl ID | ENSG00000174744 |
| Bio databases IDs | |
| Aliases | BRMS1 transcriptional repressor and anoikis regulator |
| Synonyms | breast cancer metastasis-suppressor 1, BRMS1 transcriptional repressor and anoikis regulator, BRMS1, transcriptional repressor and anoikis regulator, LOC108348098 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BRMS1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- NF-kappaB binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- chronic fatigue syndrome
- rheumatoid arthritis
- metastasis
- diverticular disease
- advanced cancer
role in cell
- expression in
- apoptosis
- activation in
- growth
- migration
- chemotaxis
- communication
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BRMS1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- positive regulation of protein deacetylation
- negative regulation of NF-kappaB transcription factor activity
- apoptotic process
- regulation of apoptotic process
- positive regulation of anoikis
- negative regulation of transforming growth factor beta receptor signaling pathway
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- Sin3-type complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- NF-kappaB binding
- protein binding
- histone deacetylase binding