IFIT1 Gene Summary [Human]
This gene encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon treatment with interferon. The encoded protein may inhibit viral replication and translational initiation. This gene is located in a cluster on chromosome 10 with five other closely related genes. There is a pseudogene for this gene on chromosome 13. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]
Details
| Type | Protein Coding |
| Official Symbol | IFIT1 |
| Official Name | interferon induced protein with tetratricopeptide repeats 1 [Source:HGNC Symbol;Acc:HGNC:5407] |
| Ensembl ID | ENSG00000185745 |
| Bio databases IDs | |
| Aliases | interferon induced protein with tetratricopeptide repeats 1 |
| Synonyms | C56, G10P1, IFI-56, IFI-56K, IFN56K, IFNAI1, IFN STIMULATED GENE 56, IFN/TETRA1, interferon induced protein with tetratricopeptide repeats 1, INTERFERON INDUCIBLE, INTERFERON INDUCIBLE 56KD, ISG56, P56, RNM561 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IFIT1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tetratricopeptide repeats
- enzyme inhibitor activity
- protein binding
- tetratricopeptide repeat
- RNA binding
Pathways
Biological processes and signaling networks where the IFIT1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- diabetic nephropathy
- diabetes mellitus
- COVID-19
- dermatomyositis
- uterine leiomyoma
- leiomyomatosis
- septic shock
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- psoriasis
role in cell
- production in
- cell viability
- expression in
- migration
- translation in
- growth
- colony formation by
- binding in
- replication in
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IFIT1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intracellular transport of viral proteins in host cell
- cellular response to exogenous dsRNA
- negative regulation of helicase activity
- defense response to virus
- cellular response to type I interferon
- positive regulation of viral genome replication
- response to virus
- negative regulation of viral genome replication
- negative regulation of protein binding
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- host cell
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding