ENOX2 Gene Summary [Human]
This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also displays prion-like properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Details
| Type | Protein Coding |
| Official Symbol | ENOX2 |
| Official Name | ecto-NOX disulfide-thiol exchanger 2 [Source:HGNC Symbol;Acc:HGNC:2259] |
| Ensembl ID | ENSG00000165675 |
| Bio databases IDs | |
| Aliases | ecto-NOX disulfide-thiol exchanger 2, tumor-associated NADH oxidase, ecto-NADPH oxidase disulfide-thiol exchanger 2 |
| Synonyms | APK1, COVA1, Cytosolic ovarian carcinoma antigen 1, ecto-NOX disulfide-thiol exchanger 2, RGD1563643, TNOX |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ENOX2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- Extracellular Space
- Nucleus
- cytosol
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ENOX2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- electron transport chain
- ultradian rhythm
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- cytosol
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- RNA binding
- oxidoreductase activity