Enox1 Gene Summary [Mouse]

Predicted to enable NADH dehydrogenase activity and protein disulfide isomerase activity. Predicted to be involved in ultradian rhythm. Predicted to be located in external side of plasma membrane and extracellular region. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; eye; and genitourinary system. Orthologous to human ENOX1 (ecto-NOX disulfide-thiol exchanger 1). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Enox1
Official Name
ecto-NOX disulfide-thiol exchanger 1 [Source:MGI Symbol;Acc:MGI:2444896]
Ensembl ID
ENSMUSG00000022012
Bio databases IDs NCBI: 239188 Ensembl: ENSMUSG00000022012
Aliases ecto-NOX disulfide-thiol exchanger 1
Synonyms B230207J08, bA64J21.1, cCNOX, CNOX, D230005D02Rik, ecto-NOX disulfide-thiol exchanger 1, LOC100363621, LOC684954, PIG38, RGD1306118
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Enox1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • protein disulfide-isomerase
  • RNA recognition motif (RRM) superfamily
  • RNA recognition motif
  • NADH2 dehydrogenase
  • enzyme
  • protein binding

Pathways

Biological processes and signaling networks where the Enox1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • schizophrenia
  • major depression
  • idiopathic scoliosis
  • restless legs syndrome
  • small vessel disease stroke
  • myopia
regulated by
role in cell
  • assembly
  • assembly in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Enox1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • ultradian rhythm

Cellular Component

Where in the cell the gene product is active
  • external side of plasma membrane
  • extracellular region
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • protein disulfide isomerase activity
  • NADH dehydrogenase activity
  • RNA binding