ALG5 Gene Summary [Human]
This gene encodes a member of the glycosyltransferase 2 family. The encoded protein participates in glucosylation of the oligomannose core in N-linked glycosylation of proteins. The addition of glucose residues to the oligomannose core is necessary to ensure substrate recognition, and therefore, effectual transfer of the oligomannose core to the nascent glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Details
| Type | Protein Coding |
| Official Symbol | ALG5 |
| Official Name | ALG5 dolichyl-phosphate beta-glucosyltransferase [Source:HGNC Symbol;Acc:HGNC:20266] |
| Ensembl ID | ENSG00000120697 |
| Bio databases IDs | |
| Aliases | ALG5 dolichyl-phosphate beta-glucosyltransferase |
| Synonyms | 1500026A19Rik, 2600005J22Rik, ALG5 dolichyl-phosphate beta-glucosyltransferase, ALG5, dolichyl-phosphate beta-glucosyltransferase, ALG5 dolichyl-phosphate β-glucosyltransferase, ALG5, dolichyl-phosphate β-glucosyltransferase, AV009521, bA421P11.2, Dolichyl-Phosphate β-Glucosyltransferase, Nero, PKD7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ALG5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyl transferase family 2
- dolichyl-phosphate beta-glucosyltransferase
- enzyme
- protein binding
- glycosyltransferase family A
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- polycystic kidney disease type 7
regulates
- asparagine
- oligosaccharide-diphosphodolichol
- PROM1
role in cell
- expression in
- cell viability
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ALG5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein N-linked glycosylation
- protein N-linked glycosylation via asparagine
- dolichol-linked oligosaccharide biosynthetic process
- determination of left/right symmetry
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- dolichyl-phosphate beta-glucosyltransferase activity