Alg5 Gene Summary [Mouse]
Predicted to enable dolichyl-phosphate beta-glucosyltransferase activity. Acts upstream of or within determination of left/right symmetry. Predicted to be active in cytoplasmic side of rough endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in polycystic kidney disease 7. Orthologous to human ALG5 (ALG5 dolichyl-phosphate beta-glucosyltransferase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Alg5 |
| Official Name | asparagine-linked glycosylation 5 (dolichyl-phosphate beta-glucosyltransferase) [Source:MGI Symbol;Acc:MGI:1913498] |
| Ensembl ID | ENSMUSG00000036632 |
| Bio databases IDs | |
| Aliases | asparagine-linked glycosylation 5 (dolichyl-phosphate beta-glucosyltransferase) |
| Synonyms | 1500026A19Rik, 2600005J22Rik, ALG5 dolichyl-phosphate beta-glucosyltransferase, ALG5, dolichyl-phosphate beta-glucosyltransferase, ALG5 dolichyl-phosphate β-glucosyltransferase, ALG5, dolichyl-phosphate β-glucosyltransferase, AV009521, bA421P11.2, Dolichyl-Phosphate β-Glucosyltransferase, Nero, PKD7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Alg5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyl transferase family 2
- dolichyl-phosphate beta-glucosyltransferase
- enzyme
- protein binding
- glycosyltransferase family A
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- polycystic kidney disease type 7
regulates
- asparagine
- oligosaccharide-diphosphodolichol
- PROM1
role in cell
- expression in
- cell viability
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Alg5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein N-linked glycosylation
- protein N-linked glycosylation via asparagine
- dolichol-linked oligosaccharide biosynthetic process
- determination of left/right symmetry
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- dolichyl-phosphate beta-glucosyltransferase activity