TENT4B Gene Summary [Human]
Enables guanylyltransferase activity and polynucleotide adenylyltransferase activity. Involved in several processes, including RNA metabolic process; negative regulation of telomere maintenance via telomerase; and regulation of mRNA stability. Located in cytoplasm and nucleolus. Part of TRAMP complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TENT4B |
| Official Name | terminal nucleotidyltransferase 4B [Source:HGNC Symbol;Acc:HGNC:30758] |
| Ensembl ID | ENSG00000121274 |
| Bio databases IDs | |
| Aliases | terminal nucleotidyltransferase 4B, TUTase3 |
| Synonyms | 5730445M16Rik, 5830428A09, PAPD5, terminal nucleotidyltransferase 4B, TRF4-2, TUT3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TENT4B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cid1 family poly A polymerase
- Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
- nucleotidyltransferase
- enzyme
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic scoliosis
- preeclampsia
- carcinoma in situ
- epithelial cancer in situ
role in cell
- expression in
- oligoadenylation in
- maturation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TENT4B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
- rRNA processing
- polyadenylation-dependent ncRNA catabolic process
- cell division
- RNA 3' uridylation
- polyadenylation-dependent snoRNA 3'-end processing
- histone mRNA catabolic process
- carbohydrate homeostasis
- RNA 3'-end processing
- mRNA 3'-end processing
- negative regulation of telomere maintenance via telomerase
- miRNA catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- nucleolus
- plasma membrane
- TRAMP complex
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- RNA binding
- telomeric RNA binding
- metal ion binding
- guanylyltransferase activity