RPA4
RPA4 Gene Summary
This gene encodes a single-stranded DNA-binding protein that is the 30-kDa subunit of the replication protein A complex. Replication protein A is an essential factor for DNA double-strand break repair and cell cycle checkpoint activation. The encoded protein localizes to DNA repair foci and may be involved in the cellular DNA damage response. This protein may also play a role in inhibiting viral replication.[provided by RefSeq, Apr 2010]
Details
| Type | Protein Coding |
| Official Symbol | RPA4 |
| Official Name | replication protein A4 [Source:HGNC Symbol;Acc:HGNC:30305] |
| Ensembl ID | ENSG00000204086 |
| Bio databases IDs | |
| Aliases | replication protein A4 |
| Synonyms | HSU24186,replication protein A4,RPA34 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- OB-fold nucleic acid binding domain
- single-stranded DNA binding
- protein binding
- oligonucleotide/oligosaccharide-binding fold of replication protein A and class 2b aminoacyl-tRNA synthetases
Pathways
Biological processes and signaling networks where the RPA4 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- XPA
- RAN
- HSPA5
- BRCA1
- RPL18A
- TMEM63A
- GNA11
- TMOD3
- FXR1
- FEN1
disease
- liver cancer
- renal cancer
- colon cancer
- cervical cancer
regulated by
- ATM
- AZD5153
- aphidicolin
regulates
- ATRIP
- ATR
role in cell
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the RPA4 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- DNA damage checkpoint
- DNA-dependent DNA replication initiation
- DNA repair
- DNA replication involved in S phase
- DNA replication
- double-strand break repair via homologous recombination
- nucleotide-excision repair
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- site of double-strand break
- DNA replication factor A complex
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- telomeric DNA binding
- single-stranded DNA binding