ZRANB3 Gene Summary [Human]
Enables ATP-dependent DNA/DNA annealing activity; K63-linked polyubiquitin modification-dependent protein binding activity; and endodeoxyribonuclease activity. Involved in several processes, including DNA metabolic process; DNA rewinding; and negative regulation of DNA recombination. Located in nuclear replication fork and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | ZRANB3 |
| Official Name | zinc finger RANBP2-type containing 3 [Source:HGNC Symbol;Acc:HGNC:25249] |
| Ensembl ID | ENSG00000121988 |
| Bio databases IDs | |
| Aliases | zinc finger RANBP2-type containing 3, annealing helicase 2 |
| Synonyms | 4933425L19Rik, AH2, C730006D09, RGD1564952, zinc finger, RAN-binding domain containing 3, zinc finger RANBP2-type containing 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZRANB3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NZF domain
- nucleic acid binding
- SNF2-related domain
- helicase superfamily c-terminal domain
- isomerase
- enzyme
- protein binding
- DNA dependent ATPase
- Helicase conserved C-terminal domain
- endonuclease
- Zn-finger in Ran binding protein and others
- single-stranded DNA binding
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- zinc finger domain
- DEAD-like helicases superfamily
- HNHc
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- morbid obesity
- sudden cardiac arrest
regulates
role in cell
- replication
- DNA damage response
- remodeling
- degradation in
- sister chromatid exchange in
- recombination in
- processing
- progression in
- reversal
- progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZRANB3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- chromatin remodeling
- response to UV
- replication fork processing
- response to DNA damage stimulus
- replication fork reversal
- negative regulation of DNA recombination
Cellular Component
Where in the cell the gene product is active
- nuclear replication fork
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- DNA helicase activity
- zinc ion binding
- protein binding
- K63-linked polyubiquitin binding
- endodeoxyribonuclease activity