CD79B
CD79B Gene Summary
The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CD79B |
| Official Name | CD79b molecule [Source:HGNC Symbol;Acc:HGNC:1699] |
| Ensembl ID | ENSG00000007312 |
| Bio databases IDs | |
| Aliases | CD79b molecule, B-cell antigen receptor complex-associated protein beta chain |
| Synonyms | AGM6,B29,CD79B antigen,CD79b molecule,IGB,Ig-beta,Ig-β,Immunoglobulin sheath beta,Immunoglobulin sheath β |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin I-set domain
- signal peptide
- protein binding
- identical protein binding
- cytoplasmic domain
- transmembrane domain
- Immunoglobulin like
- Immunoreceptor tyrosine-based activation motif
- cytosolic tail domain
- transmembrane receptor
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the CD79B gene plays a role, providing insight into its function and relevance in health or disease.
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- B Cell Development
- B Cell Receptor Signaling
- Communication between Innate and Adaptive Immune Cells
- FcγRIIB Signaling in B Lymphocytes
- p70S6K Signaling
- PI3K Signaling in B Lymphocytes
- Role of NFAT in Regulation of the Immune Response
- Systemic Lupus Erythematosus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CD79A
- ATP2B2
- PIGA
- IgM
- IKZF1
- RUFY1
- SP1
- FGFR1
- ZRANB3
- INTS5
disease
- non-Hodgkin disease
- rheumatoid arthritis
- cancer
- diffuse large B-cell lymphoma
- primary mediastinal large B-cell lymphoma
- germinal center B-cell-like diffuse large B-cell lymphoma
- high-grade B-cell lymphoma
- activated B-cell-like diffuse large B-cell lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
regulated by
- lipopolysaccharide
- LYN
- glucocorticoid
- IGHG1
- CD79B
- TNFRSF13C
- EBF1
- TCF3
- LCK
- BLK
regulates
- AKT
- ERK1/2
- MAPK1
- Ca2+
- PI3K (complex)
- CD79B
- SYK
- DOCK8
- MAPK3
- IgM
role in cell
- expression in
- proliferation
- phosphorylation in
- apoptosis
- quantity
- activation
- number
- growth
- tyrosine phosphorylation in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CD79B gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- immune response
- B cell differentiation
- signal transduction
- adaptive immune response
- B cell receptor signaling pathway
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular vesicular exosome
- B cell receptor complex
- external side of plasma membrane
- IgM B cell receptor complex
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- identical protein binding
- transmembrane signaling receptor activity
- protein binding