CUL2 Gene Summary [Human]
Enables ubiquitin protein ligase binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to act upstream of or within protein catabolic process. Located in nucleoplasm. Part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CUL2 |
| Official Name | cullin 2 [Source:HGNC Symbol;Acc:HGNC:2552] |
| Ensembl ID | ENSG00000108094 |
| Bio databases IDs | |
| Aliases | cullin 2 |
| Synonyms | 1300003D18Rik, 4932411N15Rik, cullin 2, mKIAA4106 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CUL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- transcription regulator
- binding protein
- ubiquitin-protein transferase activity
- protein binding activity, bridging
- Cullin protein neddylation domain
- Cullin family
- enzyme
- protein binding
- Cullin
Pathways
Biological processes and signaling networks where the CUL2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- Moyamoya disease
- colorectal adenoma
- colorectal adenoma formation
role in cell
- cell death
- activation in
- formation in
- apoptosis
- ubiquitination in
- formation
- degradation in
- accumulation in
- polyubiquitination in
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- nucleoli
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CUL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G1/S transition of mitotic cell cycle
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- intrinsic apoptotic signaling pathway
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- VCB complex
- cytosol
- Cul2-RING ubiquitin ligase complex
- SCF ubiquitin ligase complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- ubiquitin protein ligase binding
- protein binding, bridging