MTERF4 Gene Summary [Human]
Enables rRNA binding activity. Predicted to be involved in rRNA processing and regulation of transcription, DNA-templated. Predicted to act upstream of or within several processes, including mitochondrial transcription; protein targeting to mitochondrion; and ribosome assembly. Located in cytosol and mitochondrion. Part of mitochondrial large ribosomal subunit. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | MTERF4 |
| Official Name | mitochondrial transcription termination factor 4 [Source:HGNC Symbol;Acc:HGNC:28785] |
| Ensembl ID | ENSG00000122085 |
| Bio databases IDs | |
| Aliases | mitochondrial transcription termination factor 4 |
| Synonyms | 1810059A23Rik, 4933412H03Rik, mitochondrial transcription termination factor 4, MTEF4, MTERFD2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MTERF4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- rRNA binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
- Mitochondria
- cytosol
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MTERF4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting to mitochondrion
- transcription from mitochondrial promoter
- heart development
- camera-type eye development
- regulation of transcription, DNA-dependent
- rRNA processing
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- cytosol
- mitochondrial large ribosomal subunit
Molecular Function
What the gene product does at the molecular level
- protein binding
- double-stranded DNA binding
- rRNA binding