MND1 Gene Summary [Human]
The product of the MND1 gene associates with HOP2 (MIM 608665) to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of RAD51 (MIM 179617) and DMC1 (MIM 602721) (Chi et al., 2007 [PubMed 17639080]). Both the MND1 and HOP2 genes are indispensable for meiotic recombination.[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | MND1 |
| Official Name | meiotic nuclear divisions 1 [Source:HGNC Symbol;Acc:HGNC:24839] |
| Ensembl ID | ENSG00000121211 |
| Bio databases IDs | |
| Aliases | meiotic nuclear divisions 1 |
| Synonyms | 2610034E18Rik, GAJ, meiotic nuclear divisions 1, RGD1309007, TAC3 variant 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MND1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mnd1 HTH domain
- coiled-coil domain
- protein binding
- Leucine zipper with capping helix domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- COVID-19
- gastric adenocarcinoma
- gastric epithelial cancer
- infection by HIV-1
role in cell
- proliferation
- talazoparib sensitivity
- G1 phase
- synapsis in
- homologous recombination repair in
- oxaliplatin sensitivity
- olaparib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MND1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- reciprocal meiotic recombination
- synapsis
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding
- double-stranded DNA binding