PTGFR Gene Summary [Human]
The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PTGFR |
| Official Name | prostaglandin F receptor [Source:HGNC Symbol;Acc:HGNC:9600] |
| Ensembl ID | ENSG00000122420 |
| Bio databases IDs | |
| Aliases | prostaglandin F receptor, FP prostanoid receptor |
| Synonyms | FP, FP receptor, PF2AR, PGF, PGF2alpha, PGF2 alpha receptor, Pgf2 α -R, PGF2 α receptor, PGF receptor, prostaglandin F receptor, PROSTAGLANDIN receptor, prostanoid FP receptor, Ptgf2alpha receptor |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PTGFR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- prostaglandin F receptor
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the PTGFR gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glaucoma
- diabetic retinopathy
- ocular hypertension
- anterior uveitis
- open-angle glaucoma
- cancer
- COVID-19
- primary open-angle glaucoma
- idiopathic scoliosis
- angle-closure glaucoma
role in cell
- growth
- expression in
- proliferation
- differentiation
- phosphorylation in
- production in
- apoptosis
- induction in
- cell rounding
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- Extracellular Space
- intracellular space
- cellular membrane
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PTGFR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- G-protein coupled receptor signaling pathway
- negative regulation of apoptotic process
- positive regulation of gene expression
- positive regulation of cell proliferation
- response to estradiol stimulus
- cellular response to prostaglandin D stimulus
- response to lipopolysaccharide
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- parturition
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- prostaglandin F receptor activity