Ptgfr Gene Summary [Mouse]
Predicted to enable prostaglandin F receptor activity. Involved in positive regulation of gene expression and response to estradiol. Acts upstream of or within negative regulation of apoptotic process and response to lipopolysaccharide. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Is expressed in cloaca; genital tubercle; jaw; and viscerocranium. Orthologous to human PTGFR (prostaglandin F receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptgfr |
| Official Name | prostaglandin F receptor [Source:MGI Symbol;Acc:MGI:97796] |
| Ensembl ID | ENSMUSG00000028036 |
| Bio databases IDs | |
| Aliases | prostaglandin F receptor |
| Synonyms | FP, FP receptor, PF2AR, PGF, PGF2alpha, PGF2 alpha receptor, Pgf2 α -R, PGF2 α receptor, PGF receptor, prostaglandin F receptor, PROSTAGLANDIN receptor, prostanoid FP receptor, Ptgf2alpha receptor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptgfr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- prostaglandin F receptor
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Ptgfr gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glaucoma
- diabetic retinopathy
- ocular hypertension
- anterior uveitis
- open-angle glaucoma
- cancer
- COVID-19
- primary open-angle glaucoma
- idiopathic scoliosis
- angle-closure glaucoma
role in cell
- growth
- expression in
- proliferation
- differentiation
- phosphorylation in
- production in
- apoptosis
- induction in
- cell rounding
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- Extracellular Space
- intracellular space
- cellular membrane
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptgfr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- G-protein coupled receptor signaling pathway
- negative regulation of apoptotic process
- positive regulation of gene expression
- positive regulation of cell proliferation
- response to estradiol stimulus
- cellular response to prostaglandin D stimulus
- response to lipopolysaccharide
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- parturition
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- prostaglandin F receptor activity