RPAP2 Gene Summary [Human]
Enables RNA polymerase II CTD heptapeptide repeat phosphatase activity. Involved in dephosphorylation of RNA polymerase II C-terminal domain and snRNA transcription. Located in cytosol and nucleolus. Part of RNA polymerase II, holoenzyme. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RPAP2 |
| Official Name | RNA polymerase II associated protein 2 [Source:HGNC Symbol;Acc:HGNC:25791] |
| Ensembl ID | ENSG00000122484 |
| Bio databases IDs | |
| Aliases | RNA polymerase II associated protein 2 |
| Synonyms | C1orf82, RGD1309034, RNA polymerase II associated protein 2, Rtr1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RPAP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CTD phosphatase
- protein serine/threonine phosphatase
- enzyme
- protein binding
- Rtr1/RPAP2 family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cilia
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RPAP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- snRNA transcription
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- protein binding
- metal ion binding
- RNA polymerase core enzyme binding
- CTD phosphatase activity
- myosin phosphatase activity