NXPH1 Gene Summary [Human]

This gene is a member of the neurexophilin family and encodes a secreted protein with a variable N-terminal domain, a highly conserved, N-glycosylated central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites and axons. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
NXPH1
Official Name
neurexophilin 1 [Source:HGNC Symbol;Acc:HGNC:20693]
Ensembl ID
ENSG00000122584
Bio databases IDs NCBI: 30010 Ensembl: ENSG00000122584
Aliases neurexophilin 1
Synonyms C130005L03Rik, Nbla00697, neurexophilin 1, NPH1
Species
Human, Homo sapiens
OrthologiesMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NXPH1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Neurexophilin
  • receptor binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • schizophrenia
  • neurotic disorder
  • breast carcinoma
regulated by
  • beta-estradiol
  • NTRK2
  • FOXP1
  • testosterone
  • topotecan

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space
  • glutaminergic synapse
  • synapse

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human NXPH1 gene, providing context for its role in the cell.

Cellular Component

Where in the cell the gene product is active
  • extracellular region

Molecular Function

What the gene product does at the molecular level
  • receptor binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.