YTHDC2 Gene Summary [Human]
This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein binds to N6-methyladenosine, a common modified RNA nucleotide that is enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. Binding of proteins to this modified nucleotide may regulate mRNA translation and stability. This gene may be associated with susceptibility to pancreatic cancer in human patients, and knockdown of this gene resulted in reduced proliferation in a human liver cancer cell line. [provided by RefSeq, Sep 2016]
Details
| Type | Protein Coding |
| Official Symbol | YTHDC2 |
| Official Name | YTH domain containing 2 [Source:HGNC Symbol;Acc:HGNC:24721] |
| Ensembl ID | ENSG00000047188 |
| Bio databases IDs | |
| Aliases | YTH domain containing 2 |
| Synonyms | 3010002F02RIK, CAHL, hYTHDC2, LOC100365272, mYTHDC2, RGD1563192, YTH domain containing 2, YTH N6-methyladenosine RNA binding protein C2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human YTHDC2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Helicase associated domain (HA2)
- Oligonucleotide/oligosaccharide-binding (OB)-fold
- R3H
- EVE and YTH domains belong to the PUA superfamily
- DEAD/DEAH box helicase
- protein binding activity, bridging
- helicase superfamily c-terminal domain
- Ankyrin repeats (3 copies)
- enzyme binding
- enzyme
- protein binding
- YT521-B-like domain
- RNA helicase
- RNA dependent ATPase
- Helicase conserved C-terminal domain
- RNA binding
- AAA domain
- Helicase associated domain (HA2) Add an annotation
- R3H domain
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal cancer
- melanoma
- melanoma cancer
- non-insulin-dependent diabetes mellitus
- organismal death
- cervical cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- lung squamous cell carcinoma
regulated by
- MEIOSIN/STRA8
- cigarette smoke
- KDM2A
role in cell
- expression in
- migration
- proliferation
- differentiation
- replication in
- downregulation in
- upregulation in
- development
- prophase II
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribonucleoprotein granule
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human YTHDC2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- meiotic cell cycle
- oocyte development
- spermatid development
- germline cell cycle switching, mitotic to meiotic cell cycle
- response to interleukin-1
- response to tumor necrosis factor
Cellular Component
Where in the cell the gene product is active
- ribonucleoprotein granule
- perinuclear region of cytoplasm
- endoplasmic reticulum
- intracellular
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- RNA polymerase binding
- ATP binding
- protein binding
- RNA binding
- RNA-dependent ATPase activity
- helicase activity
- 3'-5' RNA helicase activity