HOXA7 Gene Summary [Human]
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | HOXA7 |
| Official Name | homeobox A7 [Source:HGNC Symbol;Acc:HGNC:5108] |
| Ensembl ID | ENSG00000122592 |
| Bio databases IDs | |
| Aliases | homeobox A7 |
| Synonyms | ANTP, homeobox A7, HOX1, HOX1.1, HOX1A, Hox1r5, Hoxa9, LOC100909678, LOC100911622, M6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HOXA7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- alpha helix
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- Translocation domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- homeodomain
- transcription factor activity
- protein transduction domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- peripheral T-cell lymphoma
- systemic lupus erythematosus
- leukemogenesis
- endometriosis
- pemphigus foliaceus
role in cell
- activation in
- expression in
- proliferation
- apoptosis
- morphology
- cell death
- phosphorylation in
- differentiation
- growth
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Mitochondria
- nucleoplasm
- nuclear envelope
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HOXA7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of keratinocyte differentiation
- anterior/posterior pattern specification
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of monocyte differentiation
- embryonic skeletal system morphogenesis
- regulation of transcription from RNA polymerase II promoter
- negative regulation of leukocyte migration
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- negative regulation of cell-matrix adhesion
- stem cell differentiation
- angiogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity