GMNN Gene Summary [Human]
This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | GMNN |
| Official Name | geminin DNA replication inhibitor [Source:HGNC Symbol;Acc:HGNC:17493] |
| Ensembl ID | ENSG00000112312 |
| Bio databases IDs | |
| Aliases | geminin DNA replication inhibitor |
| Synonyms | Gem, Geminin, geminin DNA replication inhibitor, geminin, DNA replication inhibitor, MGORS6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GMNN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- destruction box
- transcription co-repressor
- coiled-coil domain found in the geminin family
- transcription factor binding
- histone deacetylase binding
- coiled-coil domain
- chromatin binding
- protein binding
- Geminin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- epithelial cancer
- renal cell carcinoma
- renal cell cancer
- septic shock
- organismal death
- Meier-Gorlin syndrome type 6
- Meier-Gorlin syndrome
- Alzheimer disease
role in cell
- expression in
- proliferation
- apoptosis
- growth
- production in
- binding
- adhesion
- cell death
- phosphorylation in
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin fraction
- Cytoplasm
- cytosol
- nucleoplasm
- nucleosolic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GMNN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA replication preinitiation complex assembly
- positive regulation of chromatin binding
- negative regulation of transcription, DNA-dependent
- regulation of DNA-dependent DNA replication initiation
- negative regulation of cell cycle
- regulation of DNA replication
- negative regulation of DNA replication
- negative regulation of DNA-dependent DNA replication
- regulation of mitotic cell cycle
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- transcriptional repressor complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone deacetylase binding
- transcription corepressor activity
- chromatin binding