PSIP1 Gene Summary [Human]
Enables DNA-binding transcription factor binding activity; chromatin binding activity; and transcription coactivator activity. Involved in mRNA 5'-splice site recognition and positive regulation of transcription by RNA polymerase II. Located in heterochromatin; nuclear periphery; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PSIP1 |
| Official Name | PC4 and SFRS1 interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:9527] |
| Ensembl ID | ENSG00000164985 |
| Bio databases IDs | |
| Aliases | PC4 and SFRS1 interacting protein 1, lens epithelium-derived growth factor |
| Synonyms | DFS70, LEDGF, Lens Derived Growth Factor, p52, PAIP, PC4 and SFRS1 interacting protein 1, PC4 and SRSF1 interacting protein 1, PSIP2, SBP75 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PSIP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- double-stranded DNA binding
- PWWP domain
- transcription factor binding
- PWWP (Pro-Trp-Trp-Pro) domain
- chromatin binding
- protein binding
- charged domain
- PWWP-CR1 domain
- Lens epithelium-derived growth factor (LEDGF)
- integrase binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- osteoarthritis
- bladder carcinoma
- liver cancer
- breast cancer
- brachycephaly
- acute myeloid leukemia
- breast carcinoma
- neoplastic cell transformation
- lymphomagenesis
role in cell
- expression in
- survival
- replication in
- apoptosis
- proliferation
- cell death
- damage
- damage in
- activity
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- heterochromatin
- Cytoplasm
- cytosol
- nucleoplasm
- keratohyalin granule
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PSIP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- response to heat
- nuclear mRNA 5'-splice site recognition
- chromatin remodeling
Cellular Component
Where in the cell the gene product is active
- nucleus
- euchromatin
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- supercoiled DNA binding
- protein binding
- RNA binding