MRM2 Gene Summary [Human]
The protein encoded by this gene is a member of the S-adenosylmethionine-binding protein family. It is a nucleolar protein and it may be involved in the processing and modification of rRNA. This gene has been suggested to be involved in cell cycle control and DNA repair. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MRM2 |
| Official Name | mitochondrial rRNA methyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:16352] |
| Ensembl ID | ENSG00000122687 |
| Bio databases IDs | |
| Aliases | mitochondrial rRNA methyltransferase 2, rRNA (uridine-2'-O-)-methyltransferase, MRM2 RNA methyltransferase homolog (S. cerevisiae) |
| Synonyms | 2310037B18RIK, FJH1, FTSJ2, HEL97, mitochondrial rRNA methyltransferase 2, MTDPS17, RRMJ2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MRM2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- rRNA (uridine-2'-O-)-methyltransferase
- methyltransferase
- viral Cap-0 specific (nucleoside-2'-O-)-methyltransferase
- enzyme
- AdoMet_MTases
Pathways
Biological processes and signaling networks where the MRM2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- mitochondrial DNA depletion syndrome type 17
- pervasive developmental disorder
- major depression
- bipolar disorder
- attention deficit hyperactivity disorder
regulated by
regulates
- Mitochondrial Ribosome 39S Subunit
role in cell
- translation in
- mitochondrial respiration in
- processing in
- assembly in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Mitochondria
- mitochondrial matrix
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MRM2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rRNA 2'-O-methylation
- RNA methylation
- rRNA methylation
- rRNA processing
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- nucleolus
Molecular Function
What the gene product does at the molecular level
- rRNA (uridine-2'-O-)-methyltransferase activity