RECK Gene Summary [Human]
The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Details
| Type | Protein Coding |
| Official Symbol | RECK |
| Official Name | reversion inducing cysteine rich protein with kazal motifs [Source:HGNC Symbol;Acc:HGNC:11345] |
| Ensembl ID | ENSG00000122707 |
| Bio databases IDs | |
| Aliases | reversion inducing cysteine rich protein with kazal motifs |
| Synonyms | mRECK, reversion-inducing-cysteine-rich protein with kazal motifs, ST15 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RECK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endopeptidase inhibitor
- Wnt-protein binding
- protein binding
- metalloendopeptidase inhibitor
- coreceptor
Pathways
Biological processes and signaling networks where the RECK gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- neoplasia
- uterine serous papillary cancer
- rheumatoid arthritis
- schizophrenia
- liver cancer
- liver neoplasia
- digestive system cancer
role in cell
- proliferation
- cell death
- apoptosis
- expression in
- formation
- phosphorylation in
- cell cycle progression
- migration
- invasiveness
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- detergent resistant lipid raft fraction
- cell surface
- Extracellular Space
- cellular membrane
- myofibrils
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RECK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of establishment of blood-brain barrier
- blood vessel maturation
- positive regulation of canonical Wnt receptor signaling pathway
- extracellular matrix organization
- sprouting angiogenesis
- canonical Wnt receptor signaling pathway
- regulation of angiogenesis
- embryonic forelimb morphogenesis
- embryo implantation
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- serine-type endopeptidase inhibitor activity
- endopeptidase inhibitor activity
- protein binding
- metalloendopeptidase inhibitor activity
- Wnt-protein binding